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21st Century Folic Acid
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
USERS' SCORE
Good
Based on 56 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%

Top Medical Research Studies

7
Folic acid shows limited protective effects
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Combined treatment yields positive results.
We explored the effects of folic acid on hair loss in zebrafish larvae after exposure to different concentrations of ethanol. This study revealed how gestational ethanol exposure can harm the development of sensory hair cells. We found that even small amounts of ethanol lead to a significant decrease in hair cell count.

When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.

Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
Read More
7
Folate's role in hair growth unclear
L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes.
Limited specific effect on hair loss
We investigated the effects of folate within a well-structured study that examined its role in hair loss treatments. Although part of a marketed oral combination for diffuse hair loss, folate's specific impact was challenging to isolate because it was evaluated alongside other compounds.

Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.

Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Read More

Most Useful Reviews

8.3
Reduced hair loss
I opted to buy folic acid along with other elements like biotin and vitamins D and C due to my hair loss dilemma. It was devastating seeing strands fall during washing! I researched beneficial ingredients and found the price reasonable for the quantity. After using it, I've noticed a significant decrease in hair loss. Folic acid is particularly useful for women considering pregnancy, as it helps reduce congenital malformations. It's advised to take 400 micrograms, and consistency is key for lasting impact.
Read More
9.5
Significant decrease
Excellent product! I liked it, and my hair loss has significantly decreased. Please like if my comment assists you.
Read More
9.5
Nutrient necessity
I love the benefits of folic acid for people! It reduces hair loss rates, being vital for nourishing hair and follicles, thus mitigating scalp voids. It's beneficial not just for fine hair but can address certain alopecia cases as well.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7
  • All Researches
7
Folate's role in hair growth unclear
L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes.
Limited specific effect on hair loss
We investigated the effects of folate within a well-structured study that examined its role in hair loss treatments. Although part of a marketed oral combination for diffuse hair loss, folate's specific impact was challenging to isolate because it was evaluated alongside other compounds.

Our research utilized a minimal growth culture system to mimic the decreased activity of human hair follicular keratinocytes. We compared these cells cultured with and without four key compounds of the treatment, including folate. Our findings indicated that while the overall combination improved cell metabolism and proliferation, we couldn't clearly assess folate's individual contribution to preventing hair loss.

Ultimately, this approach revealed that L-cystine was more prominently linked to protective effects against oxidative stress, overshadowing any potential benefits from folate alone. As a result, we conclude that folate's direct effectiveness for hair growth remains ambiguous within this specific formulation and context.
Read More
7
Folic acid shows limited protective effects
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Combined treatment yields positive results.
We explored the effects of folic acid on hair loss in zebrafish larvae after exposure to different concentrations of ethanol. This study revealed how gestational ethanol exposure can harm the development of sensory hair cells. We found that even small amounts of ethanol lead to a significant decrease in hair cell count.

When we co-treated the larvae with folic acid while still exposing them to ethanol, we noted a modest increase in the number of hair cells compared to those that only received ethanol. However, despite these benefits, the hair cell counts after folic acid treatment were still significantly lower than those of the control group that did not receive any ethanol or treatment.

Unfortunately, despite folic acid showing some protective effects, the results suggest it may not be enough on its own to fully prevent hair cell loss induced by ethanol. Thus, while folic acid can have a positive influence, its isolated impact on hair loss is not entirely clear due to concurrent ethanol exposure in this study. Therefore, we conclude that while folic acid does offer some benefit, more effective protection against hair cell loss may come from other treatments, such as retinoic acid.
Read More

User Reviews

USERS' SCORE
Good
Based on 56 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
8.3
Reduced hair loss
I opted to buy folic acid along with other elements like biotin and vitamins D and C due to my hair loss dilemma. It was devastating seeing strands fall during washing! I researched beneficial ingredients and found the price reasonable for the quantity. After using it, I've noticed a significant decrease in hair loss. Folic acid is particularly useful for women considering pregnancy, as it helps reduce congenital malformations. It's advised to take 400 micrograms, and consistency is key for lasting impact.
Read More
9.5
Significant decrease
Excellent product! I liked it, and my hair loss has significantly decreased. Please like if my comment assists you.
9.5
Nutrient necessity
I love the benefits of folic acid for people! It reduces hair loss rates, being vital for nourishing hair and follicles, thus mitigating scalp voids. It's beneficial not just for fine hair but can address certain alopecia cases as well.
9.5
Postpartum necessity
This supplement is essential in the first few months after birth, as it significantly reduces hair loss and helps restore health.
10
Immediate effects
I only drink this folic acid because it’s of very good quality! The results are noticeable right away: I feel more energetic, my hair loss has ceased, and I’ve experienced new growth. My nails feel firmer, and overall I’m in better health! I highly recommend it!
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